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دانلود رایکان مقاله انگلیسی ISI با موضوع تاثیرات بیماری های جسمی و سوء مصرف های زیست محیطی بر پاسخ استرس

عنوان فارسی مقاله:

تاثیرات بیماری های جسمی و سوء مصرف های زیست محیطی بر پاسخ استرس

عنوان انگلیسی مقاله:

Editorial introduction: The effects of somatic disease and environmental insults on the stress response

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بخشی از مقاله انگلیسی :

Epilepsy is a common neurological disease that has profound effects on physiology including neuroendocrine and stress responses, and is associated with increased prevalence of depression and anxiety [11]. As reviewed by Wulsin and colleagues, and similar to that described above for cancer and IFN-alpha therapy for hepatitis C virus, recent evidence suggests that glucocorticoids are elevated in patients with temporal lobe epilepsy (TLE), one of the most frequent forms of epilepsy in adults. For instance, findings indicate that in addition to post-seizure elevations in cortisol, TLE patients fail to suppress cortisol release in response to DEX or exposure to psychosocial stressors [25,1]. Stress is a commonly reported trigger of seizures, and excess glucocorticoids may promote seizure susceptibility by increasing neuronal excitability and epileptiform activity. Further understanding potential mechanisms by which TLE may lead to abnormal stress responses has implications for the development of therapeutic strategies to reduce vulnerability to seizures and to psychiatric comorbidities.