آی اس آی پیپر

دانلود رایکان مقاله انگلیسی ISI با موضوع شاخص جدید حساسیت به انسولین از تست تحمل گلوگز خوراکی

عنوان فارسی مقاله:

شاخص جدید حساسیت به انسولین از تست تحمل گلوگز خوراکی

عنوان انگلیسی مقاله:

New insulin sensitivity index from the oral glucose tolerance test

دانلود رایگان مقاله ISI با فرمت PDF:

مشاهده توضیحات کامل و خرید ترجمه فارسی با فرمت ورد تایپ شده:

بخشی از مقاله انگلیسی :

4. Discussion

Insulin resistance not only plays an important pathophysiological role in the development of type 2 diabetes mellitus from IGT, but is also a common component of the metabolic abnormalities, which lead to the coronary heart disease, obesity, hyperlipidemia, and hypertension [13]. Therefore, there has been widespread interest in the development of techniques to assess insulin resistance or sensitivity in nondiabetic, pre-diabetic and diabetic state. To evaluate insulin resistance or insulin sensitivity, investigators have reported various methods such as the glucose clamp technique [1], the minimal model approach [14], and insulin sensitivity indexes from OGTT [4–9]. The euglycemic hyperinsulinemic clamp method is widely used measures to investigate the insulin sensitivity as gold standard. It directly measures the influence of exogenous insulin on glucose utilization under fasting steady-state conditions. However, in this method insulin is infused intravenously and represents the sensitivity of exogenously administered insulin. In addition, this method is laborious, expensive, and not routinely available for clinicians. In contrast, the OGTT is simple, safe, and less expensive. Assessment of insulin sensitivity based on OGTT data principally represents insulin sensitivity to endogenously secreted insulin to the portal system. So several formulae have been proposed for calculating insulin sensitivity indexes from OGTT data [4–9].