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دانلود رایکان مقاله انگلیسی ISI با موضوع نانو ذرات نشاندار پلی ساکرید

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نانو ذرات نشاندار پلی ساکرید

عنوان انگلیسی مقاله:

Polysaccharide-decorated nanoparticles

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4. Application of surface-modified polysaccharide nanoparticles in medicine

4.1. Pharmacokinetics and biodistribution

As it has been previously pointed out, conventional colloidal drug delivery systems are rapidly removed from the blood stream after their intravenous administration. Thus, the development of surface-modified nanoparticles appears crucial to increase the circulation time of the colloidal carriers after their intravenous administration. As complement activation and opsonization by plasma proteins are key factors involved in the uptake of particles by MPS, modified nanoparticles should present surfaces which inhibit complement activation and opsonin adsorption. Surface modification with heparin or with dextran appeared particularly appealing, as heparin was shown to increase the activity of protein H, the control protein of the complement system [79], and, depending on its configuration, soluble or crosslinked, dextran was shown to be a weak or a strong activator, of the complement system [79]. Thus, in a biomimetic approach, nanoparticles made of copolymers of dextran or heparin covalently bound to PMMA were synthesized [79].